Brian T. Luke, Ph.D.
lukeb@ncifcrf.gov

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About Me

Though I have B.S. degrees in both Biology and Chemistry (California Institute of Technology), and a Ph.D. in Theoretical Chemistry (Univeristy of Southern California), and have had the honor of doing research with two Professors who went on to win the Nobel Prize (Professor Edward B. Lewis, 1995 Nobel Prize in Physiology or Medicine, and Professor John A. Pople, 1998 Nobel Prize in Chemistry), I consider myself an Applied Mathematician.

I am currently an employee of SAIC Frederick, where I am a Senior Software Specialist and a former System Administrator of an IBM SP2 at the National Cancer Institute at Frederick's Advanced Biomedical Computing Center.

Though my background, and most of my publications, is in the field of Theoretical Chemistry, my current position at NCI Frederick has allowed me to branch out into other areas. In particular, I am heavily involved in new software development. I have been able to use my mathematical background to write programs in diverse areas. These include, but are not limited to,

  • exploring Kaplan-Meier and Cox models of survivability.
  • applying Fuzzy Sets to distinguish malignant and benign breast tumors.
  • using Evolutionary Programming do develop a very fast molecular docking program to screen large chemical libraries for putative substrates.
  • comparing Evolutionary Programming and Genetic Algorithms to search for the global energy minimum structure of flexible polypeptides.
  • applying a sequence key to find similarities in protein sequences.

I'm also actively involved in projects outside of my job at NCI Frederick. My interest in the mathematics of computation and desire to educate have lead me to develop some Educational Software for the Personal Computer. In addition, I am the owner of LearningFromTheWeb.net with the goal of providing information and links that cover the whole range of educational levels (from pre-K through college).